Erectile Dysfunction: Causes and the Steps of Treatment
Difficulty with erections is often not a sexual complaint on its own but a warning sign. Finding the right cause also determines which treatment will work.
Last medically reviewed: October 4, 2026 — Assoc. Prof. Dr. Müslüm Ergün
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About the condition
Erectile dysfunction means not being able to achieve or maintain an erection sufficient for intercourse. Occasional difficulty is normal; it needs to be assessed when it becomes persistent and starts to trouble the man concerned.
THE MOST IMPORTANT POINT IS THIS: difficulty with erections is often not simply a sexual complaint. An erection depends on the healthy working of the small blood vessels supplying the penis. These small vessels are narrower than those feeding the heart, which is why hardening of the arteries frequently shows its first sign here. In other words, in some men difficulty with erections can be a warning of cardiovascular disease years in advance. For this reason the assessment is not confined to sexual function.
The causes are usually intertwined. Vascular causes form the largest group: diabetes, high blood pressure, raised cholesterol, smoking and inactivity. Hormonal causes include low testosterone and thyroid problems. Causes arising from the nervous system include nerve damage from diabetes, spinal problems and operations in the pelvic region.
MEDICATION IS OFTEN OVERLOOKED. Some blood pressure tablets, antidepressants and certain drugs used for prostate enlargement can affect erections. Reviewing every medicine you take is an inseparable part of the assessment, because sometimes the answer is not to add a new drug but to change an existing one.
Psychological factors are real too and should not be dismissed: performance anxiety, depression, stress and relationship difficulties. But the attitude of "it is all in your head" is wrong; in most men physical and psychological causes sit side by side and each feeds the other.
Peyronie’s disease (curvature of the penis) is a separate topic but can occur alongside difficulty with erections. It is also assessed during the examination.
Who is it suitable for?
May be suitable
- Any man whose difficulty with erections has become persistent and troubles him
- Men with diabetes, high blood pressure or raised cholesterol in whom difficulty with erections has begun — vascular assessment takes priority
- Men who have had surgery in the pelvic region (prostate, bladder, rectum)
- Men who suspect the medicines they take are responsible
- Men who gain no benefit from tablets and want to discuss the next step
- Men with accompanying signs of low testosterone (tiredness, reduced desire, loss of muscle)
May not be suitable
- Men in whom sexual activity is not safe because of heart disease and who are awaiting cardiological assessment — the state of the heart is clarified first
- Men taking nitrate heart medication — PDE5 inhibitors cannot be used in these men and a different route is taken
- Men whose complaint arises solely from relationship difficulty or situational anxiety with no medical cause — counselling takes priority
- Men looking for a "guaranteed and permanent solution" — no method can make such a promise
Technology used
- Grading the complaint with standard questionnaires such as the IIEF
- Blood glucose, HbA1c, cholesterol and morning testosterone measurement
- Cardiovascular risk assessment and referral to cardiology where needed
- Penile colour Doppler ultrasound — in selected men, to assess blood flow
- A full review of the medicines being taken
Surgeon's experience
Verifiable information
- Surgeon's experience
- Assoc. Prof. Dr. Müslüm Ergün121270
Step-by-step journey
- Step 1
History and medication review
When the difficulty began, whether it came on suddenly or gradually and whether morning erections continue are all asked about. Every medicine being taken is listed. This information says a great deal about the cause.
- Step 2
Examination and blood tests
A genital examination is carried out and signs of Peyronie’s disease are looked for. Blood glucose, HbA1c, cholesterol and morning testosterone are checked. Cardiovascular risk is calculated.
- Step 3
Lifestyle and control of the underlying illness
Stopping smoking, losing weight, regular exercise and getting diabetes and blood pressure under control are the foundation of treatment. If this step is skipped, the other treatments work less well too.
- Step 4
Tablet treatment
PDE5 inhibitors are the first step. The right dose, the right timing and the fact that sexual stimulation is required are explained — these tablets do not work without stimulation. An inadequate response often comes down to incorrect use.
- Step 5
Other options if tablets are not enough
A vacuum device, injection treatment into the penis or urethral applications are discussed. These options are effective but require training in their use.
- Step 6
Penile prosthesis
For men who gain no benefit from the other treatments, it offers a lasting solution. It is an irreversible decision and needs to be discussed in detail.
Method comparison
| Method | How it is used | Who it suits | What to watch for |
|---|---|---|---|
| Lifestyle | Stopping smoking, weight, exercise | Every man | The effect builds slowly but lasts |
| PDE5 inhibitor | Tablet by mouth | First step, most men | Cannot be used by men on nitrates |
| Vacuum device | Device applied externally | Men who cannot take tablets | Takes getting used to |
| Injection | Fine needle into the penis | Men who do not respond to tablets | Risk of priapism, training essential |
| Shock wave | Low-intensity waves from outside | Selected men | The evidence is not yet settled |
| Penile prosthesis | Surgical placement | When the others are insufficient | It is irreversible |
Treatment proceeds step by step, beginning with the least invasive option. No step replaces another and none gives the same result in every man.
Risks
- Not investigating the cause: if the complaint is simply covered over with a tablet, underlying diabetes or cardiovascular disease can be missed — this is the most important warning on this page
- Side effects of PDE5 inhibitors — headache, facial flushing, blocked nose, indigestion; usually mild
- A SERIOUS DANGER IN MEN TAKING NITRATES: in men on nitrate heart medication, PDE5 inhibitors can lower blood pressure dangerously; these drugs cannot be used together
- Counterfeit tablets bought online — products of unknown content are a genuine health hazard
- A prolonged, painful erection (priapism) with injection treatment — this requires urgent assessment
- Unnecessary use of testosterone: if the level is normal, giving testosterone does not resolve difficulty with erections and carries risks of its own
- Unrealistic expectation — no method gives the same result in every man and no guarantee can be made
Alternatives
- Lifestyle change and treatment of the underlying illness — the fundamental and most neglected step
- PDE5 inhibitor tablets — first-line treatment
- Vacuum erection device — for men who cannot take the tablets
- Injection treatment into the penis — an effective option for men who do not respond to tablets
- Testosterone treatment — ONLY if the measured level is genuinely low and there are symptoms
- Sex therapy and psychological counselling — alone or alongside other treatments
- Penile prosthesis — a lasting solution when the other options prove insufficient
Recovery
After the first assessment
The cause becomes clear once the blood results are in. If there is a problem with glucose, blood pressure or cholesterol, management of it is started.
Months 1–3
The effect of lifestyle changes begins to show during this period. If tablet treatment has been started, the dose and the way it is taken are reviewed and adjusted.
Months 3–6
The response is assessed. If it is insufficient, the next step is taken. This does not mean the treatment has failed; it is a natural part of the stepwise approach.
Long term
Follow-up of the underlying vascular and metabolic conditions continues. This matters not only for sexual function but for general health.
Frequently asked questions
Can difficulty with erections be a warning of heart disease?
Yes, it can, and that is the most important message on this page. The vessels supplying the penis are narrower than those feeding the heart, which is why hardening of the arteries often shows itself here first. For that reason, in a man with difficulty achieving erections, glucose, blood pressure, cholesterol and cardiovascular risk must all be assessed.
How can you tell whether the problem is physical or psychological?
Whether the difficulty began suddenly or gradually, whether it varies with the situation and whether morning erections continue all give important clues. In most men, however, the two sit side by side; the attitude of "it is all in your head" is wrong and delays treatment.
Could the medicines I take be the cause?
Yes. Some blood pressure tablets, antidepressants and prostate medicines can affect erections. That is why every medicine you take is reviewed. Sometimes the answer is not to add a new drug but to change an existing one — do this with your doctor, never on your own.
The tablet did not work — have I no other option?
You have. But first it is worth checking: was the dose adequate, was it taken at the right time and was there sexual stimulation? These tablets do not work without stimulation, and incorrect use is a common reason for an inadequate response. If there really is no response, a vacuum device, injection treatment and the prosthesis option are discussed.
Does testosterone treatment resolve difficulty with erections?
It is only meaningful if testosterone is genuinely low and there are symptoms to match. Giving testosterone to a man whose level is normal does not resolve the difficulty; it also carries risks of its own and can affect fertility adversely. For this reason, treatment is not started without a morning testosterone measurement.
Does shock wave therapy work?
Studies of low-intensity shock wave therapy are continuing and it has been found promising in some groups of men. The level of evidence, however, is not yet settled; in whom, to what degree and for how long the effect appears has not been clearly defined. If this treatment is offered to you, it should be presented not as a standard and guaranteed solution but as an option whose evidence is still developing.
Can I have PRP or stem cell treatment?
These applications are NOT established, proven treatments for erectile dysfunction. They are at the research stage. We would advise caution towards approaches that present them as a definitive solution and charge a high fee for them. The proven steps should be worked through first.
Is it safe to buy tablets online?
No. A significant proportion of products sold online are counterfeit; what they contain is unknown, the dose is uncontrolled and they pose a serious health hazard. If you take heart medication in particular, this carries a risk to life. Medication must be obtained following a doctor’s assessment and from a pharmacy.
Does changing my lifestyle really make a difference?
Yes, and this is the most neglected step. Stopping smoking, losing weight, regular exercise and control of diabetes and blood pressure benefit both erectile function and the health of the blood vessels generally. If this step is skipped, the response to the other treatments is poorer as well.
Is the prosthesis a last resort?
Yes, it is the final step of the stepwise approach. For men who gain no benefit from the other treatments it offers a reliable and lasting solution. But because a device is placed in the place of the natural erectile tissue, it is irreversible; the decision is therefore not rushed and is discussed in detail.
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This page is for general information only and is not a substitute for medical advice.
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